基本信息
李昕，女，主任药师、教授、博士生导师，抗耐药微生物药物湖南省重点实验室主任、长沙市卫生健康医学高层次人才、湖南省芙蓉计划卫生健康高层次人才-优秀学科带头人、长沙市优秀共产党员、长沙市名医等称号。
教育经历
2010-09至2015-06，中南大学，药理学，博士，导师：李焕德
2006-09至2009-06，中南大学，药剂学，硕士，导师：李焕德
2000-09至2003-06，中南大学，药学，学士
工作经历
2025-01至今，湖南大学，附属长沙医院，教授
2024-06至今，湖南大学，附属长沙医院，主任药师
1997-08至2024-05，长沙市第三医院，药师、副主任药师、主任药师
研究领域
抗感染药物临床药理学、新药早期研发、临床研究及评价
科研项目
1. 湖南省重点研发项目，湖南省科技厅，2026-2029，主持
2. 湖南省卫计委重点项目，湖南省卫健委，2026-2028，主持
抗耐药微生物药物湖南省重点实验室，湖南省创新平台与人才项目，2023-2026，主持
3. 湖南省自然科学基金，科药联合基金项目，2020-2022，主持
4. 湖南省科技厅临床医疗技术创新引导项目，2022-2024，主持
5. 湖南省科技创新平台与人才计划-临床医疗技术示范基地，2017-2020，主持
代表论文
以5年以第一作者、通讯作者，在Angew. Chem. Int. Ed.等国内外期刊发表论文如下：
1. Xinyun Zeng, Min Wang, Pan Mao, Lei Zhang, Yongyi Yao, Ziqi Yin, Peiren Chen, Lei Wan, Wei Su, Xia Li, Xin Li*, Pei Tang, Xinxin Feng, Yugang Bai,Charge-shielding assembly enables biointerface engineering of polyhexamethylene biguanide for selective and resistance-resilient antibacterial therapy,Chemical Engineering Journal,2026, 548,180557
2. Xubo Tong, Jiaqi Li, Yingjia Tan, Jie Mao, Peiren Chen, Ziqi Yin , Mengqian Wang , Changwu Li , Guihua Liu , Yongyi Yao , Ruihan Gao, Yingying Li, Siwei Guo, Yang Deng, Wing-Leung Wong, Pan Mao, Xin Li*, Junfeng Song, Xinxin Feng. Coupled Hydrogen-Bond-Electrostatic Recognition of Phosphatidylglycerol Drives the Design of Resistance-Suppressing Miniature Peptidomimetics. J Am Chem Soc. 2026 Apr 8;148(13):14662-14679.
3. Huan Tong, Zekun Cao, Jiakai Li, Haoming Yang, Yong Qiao, Siwei Guo, Changhui Deng, Xin Li*. Imipenem and relebactam pharmacokinetics in peritoneal fluid: microdialysis reveals infection-independent penetration. Antimicrob Agents Chemother. 2026 Sep 2;70(9):e0183825.
4. Lili Zhou, Fang Yuan, Yangyang Wu, Xin Li*, Debiao Xiang.TAM-targeted nanomedicine in cancer: biological basis, therapeutic strategies, and translational perspectives. Theranostics. 2026 Jun 17;16(13):7537-7570.
5. Rong Wang; Zhimei Huang; Zhenkun Wu*; Xin Li*; Jian-hui Jiang*, Chemical Engineering of DNAzyme for Effective Biosensing and Gene Therapy, Small Methods. 2025, 9(6): e2401514.
6. Rui Yang; Debiao Xiang; Fang Yuan; Yuan Yang; Pengkai Wang; Bing Xu; Xin Li*, Unraveling Neurotoxicity Discrepancies: Comparative In vitro and In vivo Analysis of Colistin and Polymyxin B and the Underlying Mechanisms. Molecular Neurobiology. 2025, 62(4): 4562-4575.
7. Huan Tong; Yong Qiao; Yang Deng; Fang Yuan; Debiao Xiang; Siwei Guo; Bing Xu; Xin Li*,"On-off" elution mechanism facilitates the rapid LC/MS/MS-based analysis of peptide antibiotics in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2025, 1252: 124438.
8. Cong Cheng; Yuan Yuan; Fang Yuan; Xin Li*, Acute kidney injury: exploring endoplasmic reticulum stress-mediated cell death. Frontiers in Pharmacology. 2024, 15: 1308733.
9. Debiao Xiang; Lili Zhou; Rui Yang; Fang Yuan; Yilin Xu; Yuan Yang; Yong Qiao; Xin Li*, Advances in Ferroptosis-Inducing Agents by Targeted Delivery System in Cancer Therapy. International Journal of Nanomedicine. 2024, 19: 2091-2112.
10. Miaomei Tian; Bingqian Yan; Rong Jiang; Candi Liu; You Li; Bing Xu; Siwei Guo; Xin Li*, Activity of polymyxin B combined with cefepime-avibactam against the biofilms of polymyxin B-resistant Pseudomonas aeruginosa and Klebsiella pneumoniae in in vitro and in vivo models. BMC Microbiology. 2024, 24(1): 409.
11. Liguang Xiong; Debiao Xiang; Fang Yuan; Huan Tong; Rui Yang; Lili Zhou; Bing Xu; Changhui Deng; Xin Li*, Piceatannol-3’-O-β-D-glucopyranoside attenuates colistin-induced neurotoxicity by suppressing oxidative stress via the NRF2/HO-1 pathway. Biomedicine & Pharmacotherapy. 2023, 161: 114419.
12. Guiying Xiao; Fang Yuan; Yang Deng; Debiao Xiang; Liguang Xiong; Xin Li*; Yuan Li*, Polymyxin B exerts nephrotoxicity effects via inhibition of the Nrf2/NQO1 pathway‐mediated antioxidant response. Journal of Biochemical and Molecular Toxicology. 2023, 37(6): e23344.
13. You Li; Bingqian Yan; Siwei Guo; Miaomei Tian; Yuan Li; Huan Tong; Yunsong Yu; Jing Shao; Yuxia Xin; Hui Chen; Bing Xu*; Xin Li*, Pharmacokinetics of YK‐1169 in healthy subjects and pharmacokinetic/pharmacodynamic analysis by Monte Carlo simulation. British Journal of Clinical Pharmacology. 2023, 89(10): 3067-3078.
14. Yang Deng; Junyuan Gu; Xin Li*; Huan Tong; Siwei Guo; Bing Xu; You Li; Bikui Zhang; Ying Li; Haiying Huang; Guiying Xiao, Does Monitoring Total and Free Polymyxin B1 Plasma Concentrations Predict Polymyxin B-Induced Nephrotoxicity? A Retrospective Study in Critically Ill Patients. Infectious Diseases and Therapy. 2022, 11(4): 1591-1608.
15. Siwei Guo; Xin Li*; You Li; Huan Tong; Minji Wei; Bingqian Yan; Miaomei Tian; Bing Xu; Jing Shao, Sitafloxacin pharmacokinetics/pharmacodynamics against multidrug-resistant bacteria in a dynamic urinary tract infection in vitro model. Journal of Antimicrobial Chemotherapy. 2023, 78(1): 141-149.
16. Yang Deng; Xilin Luo; Xin Li*; Yisha Xiao; Bing Xu; Huan Tong, Screening of Biomarkers and Toxicity Mechanisms of Rifampicin-Induced Liver Injury Based on Targeted Bile Acid Metabolomics. Frontiers in Pharmacology. 2022, 13: 925509.
17. You Li; Siwei Guo; Xin Li*; Yunsong Yu; Bingqian Yan; Miaomei Tian; Bing Xu; Huangdu Hu, Evaluation of the in vitro synergy of polymyxin B-based combinations against polymyxin B -resistant gram-negative bacilli. Microbial Pathogenesis. 2022, 166: 105517.
18. Junchen Huang; Siwei Guo; Xin Li*; Fang Yuan; You Li; Bing Xu; Junyuan Gu; Yong Qiao, Nemonoxacin Enhances Antibacterial Activity and Anti-Resistance Mutation Ability of Vancomycin against Methicillin-Resistant Staphylococcus aureus in an In Vitro Dynamic Pharmacokinetic/Pharmacodynamic Model. Antimicrobial Agents and Chemotherapy. 2022, 66(2): e0180021.
专利成果
1.一种吸入式制剂防污染负压给药室，国家发明专利，专利号：ZL201910560409.1，排名第1
2.一种可变温的冰水浴盒，实用新型专利，专利号：ZL201920695671.2，排名第1
3.一种药敏试验卡干燥方法，国家发明专利，专利号：ZL201810470281.5，排名第2
4.用于生物等效性研究的鼻喷剂自动给药装置及其使用方法，国家发明专利，专利号：ZL 201911297178.6，排名第1
5.一种适用于培养生物被膜细菌的装置，实用新型专利，专利号：ZL 202420606220.8，排名第1
6.科研菌种数据库系统V2.0，软件著作权，登记号：2023SR0977991
荣誉奖励
2022年 长沙市名医
2021年 长沙市优秀共产党员
