崔磊，男，医学博⼠。同济⼤学医学院再⽣医学系教授，博⼠⽣导师。同济⼤学附属上海市同济医院再⽣医学临床中⼼主任。任徐州医科⼤学附属医院整形外科、南京中医药⼤学附属医院整形外科、新疆医科⼤学第⼀附属医院整形外科（博⼠⽣导师）、北京市红⼗字⾎液中⼼客座教授。曾任首都医科⼤学附属北京世纪坛医院整形美容科、中⼼实验室主任。 任中国医师协会整形外科分会委员，中国整形美容协会医学美容全国重点实验室主任。历任 中国整形美容协会抗衰老分会副会长，中国医促会肿瘤整形外科分会常委，中国医促会创面治疗分会常委。曾担任河南省、哈尔滨市特聘专家。主要从事⼲细胞、组织⼯程与再⽣医学研究及整形外科临床等⼯作。
承担国家“973”组织⼯程研究⼦项目、国家“ 863”重⼤专项、国家自然科学基⾦面上项目等多项课题。以第⼀或通讯作者发表SCI论⽂62篇；单篇他引超200次/2篇。获授权发明专利15项。主笔《黄家驷外科学》中组织⼯程章节。作为专家组组长，主持制定的《组织⼯程化 组织移植治疗技术管理规范》已由卫⽣部正式颁布施⾏。 应约为“Nature Communication” 、 “iScience” 、“Advanced Healthcare Materials” 、“Biomaterials” 、“International Journal of Biological Sciences” 、“Journal of Materials ChemistryB” 、“iScience” 、“Experimental、Cell Research”等审稿。
中华⼈民共和国建国70周年国家纪念奖章获得者（中共中央、国务院、中央军委颁布）。获国家技术发明⼆等奖(第⼆完成⼈)、教育部科技进步⼆等奖(第⼀完成⼈)、上海市 科技进步⼀等奖等多种奖励 。先后获北京市医管局“扬帆计划”、上海市“ 曙光学者”、上海市“ 优秀学科带头⼈”、上海市科委“启明星”、“启明星后”、全国优秀青年骨⼲教师等⼈才奖励及荣誉。
主要学术成果:
国际上最早进⾏组织⼯程与⼲细胞研究的重要研究者之⼀。 开创了早期组织⼯程技术体内进⾏组织再⽣与组织修复的研究，研究成果获国家技术发明⼆等奖 。开创性应用⼲细胞进⾏体内骨组织再造与骨缺损研究， 并在临床研究中得到证实。研究成果获教育部科技进步⼆等奖。
国际上最早开展脂肪⼲细胞研究的研究者。应用脂肪⼲细胞进⾏了多种组织的构建与体内组织修复⼯作。 其中，基于脂肪⼲细胞的骨组织⼯程技术，在临床研究中得到初步验证 ，成功解决骨不连、股骨头坏死、 骨良性肿瘤切除后骨缺损等临床疑难问题。
在⼲细胞体内诱导免疫耐受、体外再造组织的长期冻存、 透明关节软骨再⽣、⼤体 积器官的体外再造等领域实现了关键技术突破，为基于⼲细胞的组织器官再造奠定了多项平 台技术基础。研发并制备了多种可降解⽣物支架材料，为多种组织/器官的再造提供了重要 的材料平台技术。
发现了骨关节炎发病的新的分⼦机制，明确了多个药物治疗的靶点。为开发新的核 酸及小分⼦药物奠定了基础，研究成果发表于国际权威期刊 ，并已获国家发明专利。
在淋巴⽔肿的发病机制及⼲细胞治疗领域进⾏了重要的探索 。建立了脑胶质瘤、 骨 ⾁瘤的体外新型类器官模型，研究成果发表于国际权威杂志 。在慢性创面、导致不孕不育的 宫腔黏连、 眼表损伤等临床治疗⽅面， 开发了多项创新性技术。部分技术已经初步完成临床 转化或形成专家共识。
临床及管理⼯作：
在上海交通⼤学医学院附属上海第九⼈民医院整形外科⼯作多年， 熟练掌握疤痕整复、局部皮瓣 、 扩张器等常规⼿术。⼯作重点是显微外科进⾏组织器官修复重建， 完成断指再 植、 头皮撕脱伤、前臂皮瓣阴茎再造等多项⼿术。
熟悉公立三甲医院科室运⾏的政策法规、流程、⼈员搭配等；在团队组建、增强凝聚⼒、提升学术⽔平等⽅面，积累了丰富的经验，对医疗美容市场有较深刻的把握。
作为科主任主持⼯作后，首都医科⼤学附属北京世纪坛医院整形美容外科成功申报为“ 整 形外科专业硕⼠点”。 经过5年的建设，已多次进⼊复旦⼤学学科排名100名， 最⾼排名33名 。在作为科主任期间，主持设立的慢性创面门诊 ，是唯⼀进⼊北京市医管局特⾊科室的创面治疗学科。 建立了首都医科⼤学唯⼀、北京市第三家颅颌面治疗中⼼。 在国内较早开展了脂肪移植乳腺癌术后乳房重建的治疗。。
领衔成立了“中国整形美容协会医学美容重点实验室”，拟以此重点实验室为学术平台 ，推动全国整形美容相关研究的相互沟通、 交流与合作， 积极探索解决困扰整形美容学科发展的基础科学问题， 成为全国整形美容研究的领导者。 该实验室曾临时落户于北京世纪坛医 院并在寻找新的落户单位。
获奖情况：
1.国家技术发明二等奖（2008） 第2完成人
2.教育部科技进步二等奖（2008） 第1完成人
3.上海医学科技奖二等奖（2008） 第1完成人
4.上海医学科技奖二等奖（2008） 第3完成人
5.上海市科技进步一等奖（2008） 第3完成人
6.中华医学科技奖三等奖（2008） 第2完成人
发表⽂章(通讯作者):
1.Ren J,Zhao C,Sun R,Sun J,Lu L,Wu J,Li S,Cui L.Augmented drug resistance of osteosarcoma cells within decalcified bone matrix scaffold:The role of glutamine metabolism.Int J Cancer.2024 May 1;154(9):1626-1638.(IF:6.5，封⾯⽂章，通讯作者)
2.Shuaijun Li,Cheng Zhao,Guoying Shang,Jun-Ling Xie,Lei Cui,Qun Zhang,Jiefeng Huang.α-ketoglutarate preconditioning extends the survival of engrafted adipose-derived mesenchymal stem cells to accelerate healing of burn wounds.Exp Cell Res.2024 Jun 1;439(1):114095.(IF:4.1,通讯作者)
3.Can Wang,Qiannan Zhao,Xiaohong Zheng,et al.Decellularized brain extracellular matrix slice glioblastoma culture model recapitulates the interaction between cells and the extracellular matrix without a nutrient-oxygen gradient interference.Acta Biomater.2023,158:132.(IF:10.6，通讯作者)
4.Mao L,Wang X,Sun Y,Yang M,Chen X,Cui L,Bai W.Platelet-rich fibrin improves repair and regeneration of damaged endometrium in rats.Front Endocrinol(Lausanne).2023 Aug 8;14:1154958.
5.Yun Zhang,Shuaijun Li,Peisheng Jin,et al.Dual functions of microRNA-17 in maintaining cartilage homeostasis and protection against osteoarthritis.Nat Commun.2022;13:2447.(IF:17.7通讯作者).
6.Xiaoyu Li,Peilin Li,Can Wang,et al.A Thermo-sensitive and Injectable Hydrogel Derived from Decellularized Amniotic Membrane to Prevent Intrauterine Adhesion by Accelerating Endometrium Regeneration..Biomaterials Science.2022 May 4;10(9):2275-2286.(IF:6.2通讯作者)
7.Haiqing Tian,Hejiang Zhang,Hong Qiu,et al.Influence of maternal age on the relationship between endometrial thickness and ongoing pregnancy rates in frozen-thawed embryo transfer cycles:a retrospective analysis of 2,562 cycles.Front Endocrinol(Lausanne).2022 Apr 27:13:821753.(IF:5.6通讯作者)
8.Qian Wang,Jiefeng Huang,Shuaijun Li,et al.Fermentation supernatant of Staphylococcus aureus drives catabolism in chondrocytes via NF-κB signaling mediated increase of cholesterol metabolism.Exp Cell Res.2022,410(1):112952.(IF:3.4通讯作者)
9.Li Y,Wang G,Wang Q,et al.Exosomes Secreted from Adipose-Derived Stem Cells Are a Potential Treatment Agent for Immune-Mediated Alopecia.J Immunol Res 2022 Feb 3;2022:7471246.(IF:4.5通讯作者)
10.Guoying Zhang,Na Li,Yongjuan Tong,et al.Artemisinin derivatives inhibit adipogenic differentiation of 3T3-L1 preadipocytes through upregulation of CHOP..Biochem Biophys Res Commun.2021,557:309-315.(IF=2.985通讯作者)
11.Chenxiao Zhou,Wanchun Su,Haotian Han,et al.Mouse tail models of secondary lymphedema:fibrosis gradually worsens and is irreversible..Int J Clin Exp Pathol.2020,13(1):54-64.(IF=0.205通讯作者)
12.Xing Chen,Jingtao Sun,Xiaoyu Li,et al.Transplantation of oral mucosal epithelial cells seeded on decellularized and lyophilized amniotic membrane for the regeneration of injured endometrium.Stem Cell Res Ther.2019,10(1):107.(IF:5.1通讯作者)
13.Shang T,Li S,Zhang Y,Lu L,Cui L,Guo FF.Hypoxia promotes differentiation of adipose-derived stem cells into endothelial cells through demethylation of ephrinB2.Stem Cell Res Ther.2019 May 20;10(1):133.(IF:5.1共同通讯作者)
14.Chen X,Sun J,Li X,Mao L,Zhou Y,Cui L,Bai W.Antifibrotic Effects of Decellularized and Lyophilized Human Amniotic Membrane Transplant on the Formation of Intrauterine Adhesion.Exp Clin Transplant.2019 Apr;17(2):236-242.(IF:0.85共同通讯作者)
15.Chen X,Sun J,Li X,Mao L,Cui L,Bai W.Transplantation of oral mucosal epithelial cells seeded on decellularized and lyophilized amniotic membrane for the regeneration of injured endometrium.Stem Cell Res Ther.2019 Mar 21;10(1):107.(IF:5.1共同通讯作者)
16.Huang Z,Gu H,Yin X,Gao L,Zhang K,Zhang Y,Xu J,Wu L,Yin J,Cui L.Bone regeneration using injectable poly(γ-benzyl-L-glutamate)microspheres loaded with adipose-derived stem cells in a mouse femoral non-union model.Am J Transl Res.2019 May 15;11(5):2641-2656.(IF:3.4通讯作者)
17.Shuaijun Li,Yun Zhang,Yidan Sun,Weigang Cao,,Lei Cui.Exposure to fermentation supernatant of Staphylococcus aureus accelerated dedifferentiation of chondrocytes and production of antimicrobial peptides.J Orthop Res.2018 Jan;36(1):443-451.(IF:2.7通讯作者)
18.Ding Y,Cui L,Zhao Q,Zhang W,Sun H,Zheng L.Platelet-Rich Fibrin Accelerates Skin Wound Healing in Diabetic Mice.Ann Plast Surg.2017 Sep;79(3):e15-e19.(IF:1.4共同第一作者)
19.Gao L,Huang Z,Yan S,Zhang K,Xu S,Li G,Cui L,Yin J.Sr-HA-graft-Poly(γ-benzyl-l-glutamate)Nanocomposite Microcarriers:Controllable Sr2+Release for Accelerating Osteogenenisis and Bony Nonunion Repair.Biomacromolecules.2017 Nov 13;18(11):3742-3752.(IF:6.1共同通讯作者)
20.Aimaiti A,Maimaitiyiming A,Boyong X,Aji K,Li C,Cui L.Low-dose strontium stimulates osteogenesis but high-dose doses cause apoptosis in human adipose-derived stem cells via regulation of the ERK1/2 signaling pathway.Stem Cell Res Ther.2017 Dec 19;8(1):282.(IF:5.1通讯作者)
21.Zhang K,Song L,Wang J,Yan S,Li G,Cui L,Yin J.Strategy for constructing vascularized adipose units in poly(l-glutamic acid)hydrogel porous scaffold through inducing in-situ formation of ASCs spheroids.Acta Biomater.2017;51:246-257.(IF:7.2共同通讯作者)
22.Xue X,Liu Y,Wang Y,Meng M,Wang K,Zang X,Zhao S,Sun X,Cui L,Pan L,Liu S.MiR-21 and MiR-155 promote non-small cell lung cancer progression by downregulating SOCS1,SOCS6,and PTEN.Oncotarget.2016;7(51):84508-84519.(共同通讯作者)
23.Yan S,Zhang X,Zhang K,Di H,Feng L,Li G,Fang J,Cui L#,Chen X,Yin J.Injectable in situ forming poly(L-glutamic acid)hydrogels for cartilage tissue engineering.J.Mater.Chem.B,2016;4:947-961.(IF:5.3共同通讯作者)
24.Zhang K,He S,Yan S,Li G,Zhang D,Cui L,Yin J.Regeneration of hyaline-like cartilage and subchondral bone simultaneously by poly-(L-glutamic acid)based osteochondral scaffolds with induced autologous adipose derived stem cells.J.Mater.Chem.B,2016;4:2628-2645.(IF:5.3共同通讯作者)
25.Kaisaier A,Munila M,Abudusaimi A,Cui L.Differentiation of human adipose derived stem cells into smooth muscle cells is modulated by CaMKII.Stem Cells International.Stem Cells Int,2016(19):1-9.(IF:3.9通讯作者)
26.Li C,Bi W,Gong Y,Ding X,Guo X,Sun J,Cui L,Yu Y.Transforming growth factor-beta1 inhibits tissue engi-neering cartilage absorption via inducing the generation of regulatory T cells.J Tissue Eng Regen Med.2016;10(2):E113-20.(IF:3.1共同通讯作者)
27.Gu H,Huang Z,Yin X,Lu L,Cui L.Role of c-Jun N-terminal kinase in the osteogenic and adipogenic differentiation of human adipose-derived mesenchymal stem cells.Exp Cell Res.2015,339(1):112-21.(IF:3.4共同通讯作者)
28.Jianjun Fang,Qi Yong,Kunxi Zhang,Wentao Sun,Shifeng Yan,Lei Cui and Jingbo Yin.Novel injectable porous poly(g-benzyl-L-glutamate)microspheres for cartilage tissue engineering:preparation and evaluation.J.Mater.Chem.B,2015,3,1020–1031.(IF:5.3共同通讯作者)
29.Zhang K,Yan S,Li G,Cui L#,Yin J.In-situ birth of MSCs multicellular spheroids in poly(L-glutamic acid)/chitosan scaffold for hyaline-like cartilage regeneration.Biomaterials,2015.71:p24-34.(IF:10.3共同通讯作者)
30.Fang J,Zhang Y,Yan S,Liu Z,He S,Cui L,Yin J.Poly(L-glutamic acid)/chitosan polyelectrolyte complex porous microspheres as cell microcarriers for cartilage regeneration.Acta Biomater.2014 Jan;10(1):276-88.(IF:5.1共同通讯作者)
31.Zhang K,Zhang Y,Yan S,Gong L,Wang J,Chen X,Cui L,Yin J.Repair of an articular cartilage defect using
adipose-derived stem cells loaded on a polyelectrolyte complex scaffold based on poly(l-glutamic acid)and chitosan.Acta Biomater.2013 Jul;9(7):7276-88.(IF:5.1共同通讯作者)
32.Gong L,Zhou X,Wu Y,Zhang Y,Wang C,Zhou H,Guo F,Cui L.Proteomic analysis profile of engineered articular cartilage with chondrogenic differentiated adipose tissue-derived stem cells loaded polyglycolic acid mesh for weight-bearing area defect repair.Tissue Eng Part A.2014 Feb;20(3-4):575-87.(IF:4.5通讯作者)
33.Wang C et al,Local injection of deferoxamine improves neovascularization in ischemic diabetic random flap by increasing HIF-1αand VEGF expression.PLoS One.2014.(IF:3.5通讯作者)
34.Zou J,et al.The graft of autologous adipose-derived stem cells in the corneal stromal after mechanic damage.PLoS One.2013.(IF:3.5通讯作者)
35.Liu G,Zhang Y,Liu B,Sun J,Li W,Cui L.Bone regeneration in a canine cranial model using allogeneic adipose derived stem cells and coral scaffold.Biomaterials.2013 Apr;34(11):2655-64..(IF:7.8通讯作者)
36.Wang C,Guo F,Zhou H,Zhang Y,Xiao Z,Cui L.Proteomic profiling of tissue-engineered blood vessel walls constructed by adipose-derived stem cells.Tissue Eng Part A.2013;19:415-25.(IF:4.5通讯作者)
37.17.Shifeng Yan,Kunxi Zhang,Zhiwen Liu,Xin Zhang,Lu Gan,Bin Cao,Xuesi Chen,Lei Cui and Jingbo Yin.Fabrication of poly(L-glutamic acid)/chitosan polyelectrolyte complex porous scaffolds for tissue engineering.J.Mater.Chem.B,2013,1,1541–1551.(IF:5.3共同通讯作者)
38.Xu J,Chen Y,Yue Y,Sun J,Cui L.Reconstruction of epidural fat with engineered adipose tissue from adipose derived stem cells and PLGA in the rabbit dorsal laminectomy model.Biomaterials.2012;33(29):6965-73.(IF:7.8通讯作者)
39.Chen F,Zhang W,Wu W,Jin Y,Cen L,Kretlow JD,Gao W,Dai Z,Wang J,Zhou G,Liu W,Cui L,Cao Y.Cryopreservation of tissue-engineered epithelial sheets in trehalose.Biomaterials.2011 Nov;32(33):8426-35.(IF:7.8，通讯作者)
40.Gao WC,Ma SL,Cui L.Adipose-derived stem cells accelerate neovascularization in ischemic diabetic skin flap via expression of hypoxia-inducible factor-1.J Cell Mol Med.2011;15:2575-85.(IF:4.5，通讯作者)
41.Gu H,Guo F,Zhou X,Gong L,Zhang Y,Zhai W,Chen L,Cen L,Yin S,Chang J,Cui L.The stimulation of osteogenic differentiation of human adipose-derived stem cells by ionic products from akermanite dissolution via activation of the ERK pathway.Biomaterials.2011;32:7023-33.(IF:7.8，通讯作者)
42.Cao B,Yan S,Zhang K,Song Z,Chen X,Cui L,Yin J.Layer-by-layer assembled multilayer films of methoxypoly(ethylene glycol)-block-poly(!,l-glutamic acid)and chitosan with reduced cell adhesion.Macromol Biosci.2011;11:1211-7(IF:3.2通讯作者)
43.Yan S,Yin J,Cui L,Yang Y,Chen X.Apatite-forming ability of bioactive poly(l-lactic acid)/grafted silica nanocomposites in simulated body fluid.Colloids Surf B Biointerfaces.2011;86(1):218-24.(IF:2.5通讯作者)
44.Cao B,Yan S,Zhang K,Song Z,Cao T,Chen X,Cui L,Yin J.A poly(acrylic acid)-block-poly(L-glutamic acid)diblock copolymer with improved cell adhesion for surface modification.Macromol Biosci.2011;11(7):970-7.(IF:4.3通讯作者)
45.Cao B,Yin J,Yan S,Cui L,Chen X,Xie Y.Porous scaffolds based on cross-linking of poly(L-glutamic acid).Macromol Biosci.2011;11(3):427-34(IF:4.3通讯作者)
46.Yin S,Cen L,Wang C,Zhao G,Sun J,Liu W,Cao Y,Cui L.Chondrogenic transdifferentiation of human dermal fibroblasts stimulated with cartilage-derived morphogenetic protein 1.Tissue Eng Part A.2010;16:1633-43.(IF:4.5通讯作者)
47.Yuan J,Zhang WJ,Liu G,Wei M,Qi ZL,Liu W,Cui L,Cao YL.Repair of canine mandibular bone defects with bone marrow stromal cells and coral.Tissue Eng Part A.2010;16:1385-94.(IF:4.5通讯作者)
48.Wang C,Yin S,Cen L,Liu Q,Liu W,Cao Y,Cui L.Differentiation of adipose-derived stem cells into contractile smooth muscle cells induced by transforming growth factor-beta1 and bone morphogenetic protein-4.Tissue Eng Part A.2010;16:1201-13.(IF:4.5通讯作者)
49.Liu G,Li Y,Sun J,Zhou H,Zhang W,Cui L,Cao Y.In vitro and in vivo evaluation of osteogenesis of human umbilical cord blood-derived mesenchymal stem cells on partially demineralized bone matrix.Tissue Eng Part A.2010;16:971-82.(IF:4.5通讯作者)
50.Wang C,Cen L,Yin S,Liu Q,Liu W,Cao Y,Cui L.A small diameter elastic blood vessel wall prepared under
pulsatile conditions from polyglycolic acid mesh and smooth muscle cells differentiated from adipose-derived stem cells.Biomaterials.2010;31:621-30.(IF:7.8通讯作者)
51.Wang HJ,Liu GP,Zhou GD,Cen L,Cui L,Cao Y.Comparative investigation of viability,metabolism and osteogenic capability of tissue-engineered bone preserved in sealed osteogenic media at 37 degrees C and 4 degrees C.BIOMEDICAL MATERIALS 2010;5:035010(IF:1.8通讯作者)
52.Liu Q,Cen L,Zhou H,Yin S,Liu G,Liu W,Cao Y,Cui L.The role of the extracellular signal-related kinase
signaling pathway in osteogenic differentiation of human adipose-derived stem cells and in adipogenic transition initiated by dexamethasone.Tissue Eng Part A.2009;15:3487-97.(IF:4.5通讯作者)
53.Cui L,Wu YH,Cen L,et al.Repair of Articular cartilage defect in non-weight bearing areas using adipose derived stem cells loaded polyglycolic acid mesh.Biomaterials.2009;30:2683-2693(IF:7.8通讯作者)
54.Zhao GQ,Yin S,Cen L,et al.In vitro engineering of fibrocartilage using CDMP1 induced dermal fibroblasts and polyglycolide.Biomaterials.2009;30:3241-50.(IF:7.8通讯作者)
55.Lian Cen,Koon Gee Neoh,Jian Sun,et al.Labeling of adipose derived stem cells by oleic acid modified magnetic nanoparticles.Advanced Func.Mater.2009;19:1158-66.(IF:9.6通讯作者)
56.Liu Q,Cen L,Yin S,et al.A comparative study of proliferation and osteogenic differentiation of adipose-derivedstem cells on akermanite and beta-TCP ceramics.Biomaterials.2008;29:4792-4799.(IF:7.8通讯作者)
57.Luo K,Yin J,Song Z,et al.Biodegradable Interpolyelectrolyte Complexes Based on Methoxy Poly(ethylene glycol)-b-poly(alpha,l-glutamic acid)and Chitosan.Biomacromolecules.2008;9:2653-61(IF:5.1通讯作者)
58.Liu G,Zhou H,Li Y,et al.Evaluation of the viability and osteogenic differentiation of cryopreserved human adipose-derived stem cells.Cryobiology.2008;57:18-24,(IF:2.8通讯作者)
59.Cui L,Liu B,Liu GP,et al.Repair of cranial bone defects with adipose derived stem cells and coral scaffold in a canine model.Biomaterials.2007;28:5477-5486(IF:7.8第一作者)
60.Jiang XG,Ye ML,Jiang XM,et al.Exploring the bone proteome:from protein identification to protein function.Method development of efficient protein extraction in bone tissue for proteome analysis,J.Proteome Res.,2007,6:2287-2294.(IF:5.6通讯作者)
61.Cui L,Yin S,Liu W,Li NL,Zhang WJ,Cao YL.Expanded adipose derived stem cells suppress mixed lymphocyte reaction by secretion of prostaglandin E2.Tissue Eng,2007;13:1185-95(IF:4.5第一作者)
62.Jie Yuan,Cui L,Wen Jie Zhanga,Wei Liu,Yilin Cao.Repair of canine mandibular bone defects with bone marrow stromal cells and porous b-tricalcium phosphate.Biomaterials.2007;28:1005-13(IF:7.8共同第一作者)
