信号转导调控和肿瘤转移、复发实验室
基本信息：
唐小龙，博士，湖南大学生命医学交叉研究院，教授/博士生导师
联系方式：xltang@hnu.edu.cn
教育经历：
2009/9–2014/12，华东师范大学生命医学研究所、上海市调控生物学重点实验室，理学博士
2005/9–2009/6，华东师范大学生物技术专业，理学学士
科研工作经历：
2015/7–2018/6，武汉大学-深圳大学，博士后研究。
2018/7–2022/5， 深圳大学医学部，副研究员。
2022/6-至今，湖南大学生命医学交叉研究院，教授。
研究方向：
近年来实验室主要围绕信号转导调控在肿瘤转移复发和衰老相关疾病中的作用开展研究。相关研究成果发表在Nature Communications （2017/2021），Cancer Research （2013），EMBO J （2020），Science Advances（2020），Nucleic Acids Research （2020），Oncogene（2018），Communications Biology （2021），Nature Metabolism （2019），Theranostics （2022），Journal of Investigative Dermatology （2022）等国际主流杂志。重要研究发现包括：揭示了G蛋白偶联受体GPR116调控乳腺癌转移及相关机制；系统地阐释了去乙酰化酶SIRT7在乳腺癌转移、耐药、复发中的信号调控机制；发现了SIRT7在血管内皮、毛囊干细胞等组织器官中的抗衰老作用。实验室现开展的研究包括以下：
1. 信号转导调控和肿瘤转移复发
1）G蛋白偶联受体（GPCRs）调控肿瘤转移复发的机制研究。
2）蛋白质翻译后修饰影响肿瘤细胞休眠以及转移复发的机制研究。
2. 血管稳态和相关疾病：受体信号转导和血管稳态及机体代谢的调节。
实验室热忱期待各位同学和同仁的加入，共同发展！欢迎本科生同学加入实验室实习、体验！
联系方式：xltang@hnu.edu.cn
科研项目/个人荣誉：
1. 湖南大学高层次人才启动基金，2022-2025.
2. 深圳市国内高层次人才，2018-2023。
3. 国家自然科学基金重大项目，DNA同源重组及DNA双链断裂修复的分子机制研究，32090033，2021-2025，研究骨干。
4. 深圳市基础研究重点项目，中药化合物组合抗肿瘤研究，2021N063，2022-2024，研究骨干。
5. 国家自然科学基金面上项目，SIRT7的乙酰葡萄糖胺修饰在肝癌中的功能和机制研究，2020/01–2023/12，81972602，主持。
6. 国家自然科学基金青年基金，SMAD4-SIRT7信号轴调控结直肠癌发展及转移的机制研究，2018/01–2020/12，81702909，主持。
7. 中国博士后科学基金面上项目，SIRT7调控乳腺癌转移的机制研究，2015M582419，2015/10–2017/10，主持。
研究成果（* Corresponding authors，# Co-first authors）：
1. Guo Li, Xiaolong Tang*, Shuping Zhang, Ben Wang, Zhili Deng, Hongfu Xie, Baohua Liu, Ji Li*. (2022). Aging-conferred SIRT7 Decline Inhibits Rosacea-like Skin Inflammation via Modulating TLR2-NF-κB Signaling. Journal of Investigative Dermatology, 2022 Apr 10; S0022-202X (22)00273-1. (IF: 8.6).
2. Yalan Wu, Xiaolong Tang, Sharen Lee, Huiling Hong, Xiaoyun Cao, Chi Wai Lau, Baohua Liu, Ajay Chawla, Ronald Ching Wan Ma, Yu Huang, Kathy O Lui, Xiao Yu Tian*. (2022). Endothelial PPARdelta facilitates the post-ischemic vascular repair through interaction with HIF1alpha. Theranostics, 12(4):1855-1869. (IF: 11.5).
3. Xiaolong Tang, Guo Li, Lei Shi, Fengting Su, Minxian Qian, Zuojun Liu, Yuan Meng, Shimin Sun, Ji Li, Baohua Liu*. (2021). Combined intermittent fasting and ERK inhibition enhance the anti-tumor effects of chemotherapy via the GSK3β-SIRT7 axis. Nature Communications, 2021 Aug 25;12(1):5058. (焦点论文) (IF: 14.92).
4. Xiaolong Tang#*, Lizhi Cheng#, Guo Li#, Yong-Ming Yan, Fengting Su, Dan-Ling Huang, Shuping Zhang, Zuojun Liu, Minxian Qian, Ji Li, Yong-Xian Cheng*, Baohua Liu*. (2021). Novel small-molecule compound D6 overcomes EGFR-T790M-mediated resistance in non-small cell lung cancer. Communications Biology, 2021 Dec 13; 4(1):1391. (IF: 6.24)
5. Fengting Su#, Xiaolong Tang#*, Guo Li, Andreas Koeberle, Baohua Liu*. (2021). SIRT7–SREBP1 restrains cancer cell metabolic reprogramming by upregulating IDH1. Genome Instability & Disease, (2021) 2:126–137.
6. Guo Li#, Xiaolong Tang#, Shuping Zhang, Meiling Jin, Ming Wang, Zhili Deng, Zuojun Liu, Minxian Qian, Wei Shi, Zimei Wang, Hongfu Xie, Ji Li*, Baohua Liu*. (2020). SIRT7 evokes quiescent hair follicle stem cells and ensures hair growth in mice. EMBO J, 2020 Sep 15;39(18):e104365. (IF: 11.6).
7. Xiaolong Tang, Guo Li, Fengting Su, Yanling Cai, Lei Shi, Yuan Meng, ZuoJun Liu, Jie Sun, Ming Wang, Minxian Qian, Zimei Wang, Xingzhi Xu, Yong-Xian Cheng, Wei-Guo Zhu, Baohua Liu*. (2020). HDAC8 cooperates with SMAD3/4 complex to suppress SIRT7 and promote cell survival and migration. Nucleic Acids Research, 2020 Apr 6; 48(6):2912-2923.(IF: 16.97).
8. Shimin Sun#, Weifeng Qin#, Xiaolong Tang#, Yuan Meng, Wenjing Hu, Shuju Zhang, Minxian Qian, Zuojun Liu, Xinyue Cao, Qiuxiang Pang, Bosheng Zhao, Zimei Wang, Zhongjun Zhou, Baohua Liu*. (2020).Vascular endothelium–targeted Sirt7 gene therapy rejuvenates blood vessels and extends life span in a Hutchinson-Gilford progeria model. Science Advances, 2020 Feb 19;6(8):eaay5556. (IF: 14.14).
9. Zuojun Liu#, Minxian Qian#, Xiaolong Tang, Wenjing Hu, Shimin Sun, Guo Li, Shuju Zhang, Fanbiao Meng, Xinyue Cao, Jie Sun, Cheng Xu, Bing Tan, Qiuxiang Pang, Bosheng Zhao, Zimei Wang, Youfei Guan, Xiongzhong Ruan, Baohua Liu*. (2019). SIRT7 couples light-driven body temperature cues to hepatic circadian phase coherence and gluconeogenesis. Nature Metabolism，2019, 1, pages1141–1156. (IF: 13.7).
10. Lei Shi#, Xiaolong Tang#, Minxian Qian, Zuojun Liu, Fanbiao Meng, Li Fu, Zimei Wang, Wei-Guo Zhu, Jian-Dong Huang, Zhongjun Zhou, Baohua Liu*. (2018). A SIRT1-centered circuitry regulates breast cancer stemness and metastasis. Oncogene, 2018 Dec;37(49):6299-6315. (IF: 9.87).
11. Xiaolong Tang#, Lei Shi#, Ni Xie#, Zuojun Liu, Minxian Qian, Fanbiao Meng, Qingyang Xu, Minyan Zhou, Xinyue Cao, Wei-Guo Zhu, Baohua Liu*. (2017). SIRT7 antagonizes TGF-β signaling and inhibits breast cancer metastasis, Nature Communications, 2017 Aug 22; 8(1):318. (IF: 14.92).
12. Xiaolong Tang#, Rongrong Jin#, Guojun Qu, Xiu Wang, Zhenxi Li, Zengjin Yuan, Chen Zhao, Stefan Siwko, Tieliu Shi, Ping Wang, Jianru Xiao, Mingyao Liu, Jian Luo*. (2013). GPR116, an adhesion G-protein-coupled receptor, promotes breast cancer metastasis via the Galphaq-p63RhoGEF-Rho GTPase pathway. Cancer Research, 2013, 73(20):6206-6218. (IF: 12.7).
13. Xiaolong Tang, Ying Wang, Dali Li, Jian Luo*, Mingyao Liu*. (2012). Orphan G protein-coupled receptors (GPCRs): biological functions and potential drug targets, Acta Pharmacologica Sinica, 2012, 33(3):363-371. (IF: 6.15).
14. Qian, M., Liu, Z., Peng, L., Tang, X., Meng, F., Ao, Y., Zhou, M., Wang, M., Cao, X., Qin, B., et al. (2018). Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria. Elife.
15. Tao Zheng, Li-Zhi Cheng, Yong-Ming Yan, Fu-Rong Xu, Xiao-Long Tang, Xiao-Zhen Li, Fu-Ying Qin, Bao-Hua Liu, Yong-Xian Cheng. (2018). Compounds from the Roots of Codonopsis pilosula and Their SIRT1 Regulatory Activity. Natural Product Communications, volume: 13 issue: 1.
16. Ming Wang, Lulu Wang, Minxian Qian, Xiaolong Tang, Zuojun Liu, Yiwei Lai, Ying Ao, Yinghua Huang, Yuan Meng, Lei Shi, Linyuan Peng, Xinyue Cao, Zimei Wang, Baoming Qin, Baohua Liu*. PML2-mediated thread-like nuclear bodies mark deep senescence in Hutchinson-Gilford progeria syndrome. Aging Cell, 2020.
17. Linyuan Peng, Minxian Qian, Zuojun Liu, Xiaolong Tang, Yue Jiang, Shimin Sun, Xinyue Cao, Qiuxiang Pang, Baohua Liu*. eacetylase-independent function of SIRT6 couples GATA4 transcription factor and epigenetic activation against cardiomyocyte apoptosis. Nucleic Acids Research, 2020.
18. Meng, F., Qian, M., Peng, B., Peng, L., Wang, X., Zheng, K., Liu, Z., Tang, X., Zhang, S., Sun, S., Cao, X., Pang, Q., Zhao, B., Ma, W., Songyang, Z., Xu, B., Zhu, W. G., Xu, X., & Liu, B*. (2020). Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiates the DNA damage response and repair in humans and mice. eLife, 9, e55828.
19. Jian Luo, Xiaolong Tang and Anliang Dong, Induction of cancer cell senescence: Role of caffeic acid 3, 4-dihydroxy-phenethyl ester, Springer Press, Volume 3, 2014.
