人才队伍

梅杨

时间:2021年08月23日 20:00 点击: 字体大小:

基本情况

湖南大学,生命医学交叉研究院,教授/博士生导师。Email: yanmei@hnu.edu.cn my1986sp@163.com


教育经历

2008 – 2013 厦门大学,生命科学学院,细胞生物学专业(细胞应激生物学国家重点实验室),博士

2004 – 2008 华中师范大学,生命科学学院,生物技术专业,本科


工作经历

2020-至今 湖南大学,教授/博导(岳麓学者)

2018-2020 美国西北大学,Feinberg 医学院,病理系,研究助理

2013-2018 美国西北大学,Feinberg 医学院,病理系,博士后


学术兼职

美国血液学会(ASH)会员

细胞生物学学会会员


研究领域

(1) 骨髓增生异常综合症疾病模型

(2) 红细胞发育及贫血

(3) 炎症因子及免疫调节

(4) 基因转录与表达调控

(5) 造血干细胞生物学


科研项目

2017 Lurie Cancer Center-NUCATS Joint Translational Bridge Program Award, Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Co-PI

2020 湖南大学高层次人才启动基金,主持

2020 长沙市自然科学基金,主持

2021 湖南省自然科学基金,主持

2021 国家自然科学基金青年基金,主持

2021 美国血液学会(ASHGlobal Research Award,主持


代表论文

First author/Co-first author (#)

1. Yang Mei, Yijie Liu, Peng Ji. Understanding terminal erythropoiesis: An update on chromatin condensation, enucleation, and reticulocyte maturation. Blood Reviews. 2021. 46:100740. (Co-corresponding author) (IF=6.314)

2.Yang Mei#, Samuel E. Weinberg#, Lihui Zhao, Adam Frink, Chao Qi, Amir Behdad, Peng Ji, Risk stratification of hospitalized COVID-19 patients through comparative studies of laboratory results with influenza.EClinicalMedicine. 2020, 100475.

(Comment in: Differentiating diagnosis of COVID-19 or influenza in patients based on laboratory data during flu season. Shuwen Liu, Chungen Pan. EClinicalMedicine. 2020. 26, 100475.)

3. Yang Mei, Xu Han, Yijie Liu, Jing Yang, Ronen Sumagin, and Peng Ji. Diaphanous-related formin mDia2 regulates beta2 integrins to control hematopoietic stem and progenitor cell engraftment. Nat Communications. 2020 Jun 23;11(1):3172. (Co-corresponding author) (IF=11.878)

4. Yang Mei, Baobing Zhao, Ashley A Basiorka, Jing Yang, Lan Cao, JingxinZhang, Alan List, and Peng Ji. Age-related inflammatory bone marrow microenvironment induces ineffective erythropoiesis mimicking del(5q) MDS. Leukemia. 2018,32(4):1023-1033. (IF=10.023)

5. Yang Mei, Gong Feng, Nina Rahimi, Baobing Zhao, Jingxin Zhang, Lan Cao, Jing Yang, Juehua Gao, Yihua Chen, Ronen Sumagin, William A. Muller, Ling Zhang and Peng Ji. Loss of mDia1 causes neutropenia via attenuated CD11b endocytosis and increased neutrophil adhesion to the endothelium. Blood Advances. 2017,1:1650-1656. (IF=4.622)

6. Xuehui Li#, Yang Mei#, Bowen Yan#, Eric Vitriol, Suming Huang, Peng Ji, and Yi Qiu. Histone deacetylase 6 regulates cytokinesis and erythrocyte enucleation through deacetylation of formin protein mDia2. Haematologica. 2017, 102(6): 984-994. (IF=9.09)

7. Yang Mei, Baobing Zhao, Jing Yang, Juehua Gao, Amittha Wickrema, Dehua Wang, Yihua Chen, Peng Ji. Ineffective Erythropoiesis Caused by Binucleated Late-Stage Erythroblasts in mDia2 Hematopoietic Specific Knockout Mice. Haematologica. 2016, 101(1): e1–e5. (IF=9.09)

8. Ganesan Keerthivasan#, Yang Mei#, Baobing Zhao, Ling Zhang, Chad E. Harris, Juehua Gao, Ashley A. Basiorka, Matthew J. Schipma, James McElherne, Jing Yang, Amit K. Verma, Andrea Pellagatti, Jacqueline Boultwood, Alan F. List, David A. Williams, and Peng Ji. Aberrant overexpression of CD14 on granulocytes sensitizes the innate immune response in mDia1 heterozygous del(5q) myelodysplastic syndromes. Blood. 2014, 124(5): 780-90. (IF=17.543)

(Comment in: Errant innate immune signaling in del(5q) MDS. Starczynowski DT. Blood. 2014, 31; 124(5): 669-71.)

9.  Yang Mei#, Zhanxiang Wang#, Lei Zhang#, Yiru Zhang, Xiaoyu Li, Huihui Liu, Jing Ye, and Han You. Regulation of neuroblastoma differentiation by forkhead transcription factors FOXO1/3/4 through the receptor tyrosine kinase PDGFRA. Proc Natl Acad Sci U S A. 2012, 109(13): 4898-903. (IF=10.620)

10. Yang Mei#, Yiru Zhang#, Kazuo Yamamoto, Wei Xie, Tak W. Mak and Han You. FOXO3a-dependent regulation of Pink1 (Park6) mediates survival signaling in response to cytokine deprivation. Proc Natl AcadSci U S A. 2009, 106(13): 5153-8. (IF=10.620)

(Editors' Choice, Cell Survival, In the Pink1 with FOXO3a. Elizabeth MA, Sci. Signal. 2009, 2 (65), ec122.)

11. Yijie Liu, Yang Mei, Xu Han, Farida V Korobova, Miguel A Prado, Jing Yang, Zhangli Peng, Joao Paulo, Steven Gygi, Daniel Finley, Peng Ji. Membrane skeleton modulates erythroid proteome remodeling and organelle clearance. Blood. 2020. doi:10.1182/blood.2020006673. (IF=17.543)

12. Baobing Zhao, Yang Mei, Lan Cao, Jingxin Zhang, Ronen Sumagin, Jing Yang, Juehua Gao, Matthew J. Schipma, Yanfeng Wang, Chelsea Thorsheim, Liang Zhao, Timothy Stalker, Brady Stein, Qiang Jeremy Wen, John D. Crispino, Charles S. Abrams, and Peng Ji. Loss of pleckstrin-2 reverts lethality and vascular occlusions in JAK2V617F-positive myeloproliferative neoplasms. J Clin Invest. 2018, 128(1):125-140. (IF=13.393)

13. Baobing Zhao, Yang Mei, Matthew J. Schipma, Eric Wayne Roth, Reiner Bleher, Joshua Z. Rappoport, AmitthaWickrema, Jing Yang, Peng Ji, Nuclear Condensation during Mouse Erythropoiesis Requires Caspase-3-Mediated Nuclear Opening, Dev Cell. 2016, 36(5):498-510. (IF=10.129)

14. Lei Zhang, Yang Mei, Nai-yang Fu, Li Guan, Wei Xie, Hui-hui Liu, Chun-dong Yu, Zhenyu Yin, Victor C. Yu, and Han You. TRIM39 regulates cell cycle progression and DNA damage responses via stabilizing p21. Proc Natl Acad Sci U S A. 2012, 109(51):20937-42. (IF=10.620)


奖励与荣誉

2007 国家奖学金,教育部

2012 博士研究生国家奖学金,教育部

2015 Katten Muchin Rosenman Travel Scholarship award, Northwestern University

2016 ASH Abstract Achievement Award, 美国血液学会

2017 Katten Muchin Rosenman Travel Scholarship award, Northwestern University

2017 Lurie Cancer Center-NUCATS Joint Translational Bridge Program Award, Northwestern University

2017 OPA Professional Development Travel Awards, Northwestern University

2021 湖南省“百人计划”青年项目,湖南省

2021 ASH“全球研究奖”, 美国血液学会