基本情况
湖南大学，生命医学交叉研究院，教授/博士生导师，岳麓学者。Email: yanmei@hnu.edu.cn ；my1986sp@163.com
教育经历
2008 – 2013 厦门大学，生命科学学院，细胞生物学专业（细胞应激生物学国家重点实验室），博士
2004 – 2008 华中师范大学，生命科学学院，生物技术专业，本科
工作经历
2020-至今 湖南大学，教授/博导
2018-2020 美国西北大学，Feinberg 医学院，病理系，研究助理
2013-2018 美国西北大学，Feinberg 医学院，病理系，博士后
学术兼职
美国血液学会(ASH)会员
细胞生物学学会会员
Cancer Biology & Medicine青年编委
研究领域
(1) 骨髓增生异常综合症疾病模型
(2) 红细胞发育及贫血
(3) 炎症因子及免疫调节
(4) 基因转录与表达调控
(5) 造血干细胞生物学
科研项目
2017 Lurie Cancer Center-NUCATS Joint Translational Bridge Program Award, Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Co-PI
2020 湖南大学高层次人才启动基金，主持
2020 长沙市自然科学基金，主持
2021 湖南省自然科学基金，主持
2021 国家自然科学基金青年项目，主持
2021 美国血液学会（ASH）Global Research Award，主持
2022 国家自然科学基金面上项目，主持
2022 湖南省优秀青年基金项目，主持
2022 湖南大学优青培育计划，主持
2023 国家自然科学基金青年项目，课题组博士后苏孟主持
代表论文
First author/Co-first author (#)
1. Xinshu Xie#, Meng Su#, Kehan Ren, Xuezhen Ma, Zhiyi Lv, Zhaofeng Li, Yang Mei*, Peng Ji*. Clonal hematopoiesis and bone marrow inflammation. Transl Res. 2022. S1931-5244(22)00246-8. (Co-corresponding author) (IF= 10.171)
2. Yang Mei#*, Kehan Ren#, Yijie Liu, Annabel Ma, Zongjun Xia, Xu Han, Ermin Li, Hamza Tariq, Haiyan Bao, Xinshu Xie, Cheng Zou, Dingxiao Zhang, Zhaofeng Li, Lili Dong, Amit Verma, Xinyan Lu, Yasmin Abaza, Jessica K Altman, Madina Sukhanova, Jing Yang, Peng Ji*. Bone marrow–confined IL-6 signaling mediates the progression of myelodysplastic syndromes to acute myeloid leukemia. J Clin Invest. 2022. 132(17): e152673. (Co-corresponding author) (IF= 19.456, Cover Story)
3. Yang Mei*, Yijie Liu, Peng Ji*. Understanding terminal erythropoiesis: An update on chromatin condensation, enucleation, and reticulocyte maturation. Blood Reviews. 2021. 46:100740. (Co-corresponding author) (IF= 10.626)
4. Yijie Liu, Yang Mei, Xu Han, Farida V Korobova, Miguel A Prado, Jing Yang, Zhangli Peng, Joao Paulo, Steven Gygi, Daniel Finley, Peng Ji*. Membrane skeleton modulates erythroid proteome remodeling and organelle clearance. Blood. 2020. 137(3):398-409. (IF= 25.476, Cover Story)
5. Yang Mei#, Samuel E. Weinberg#, Lihui Zhao, Adam Frink, Chao Qi, Amir Behdad, Peng Ji*. Risk stratification of hospitalized COVID-19 patients through comparative studies of laboratory results with influenza. EClinicalMedicine. 2020, 100475. (IF= 17.033)
Comment in: Differentiating diagnosis of COVID-19 or influenza in patients based on laboratory data during flu season. Shuwen Liu, Chungen Pan. EClinicalMedicine. 2020. 26, 100475.)
6. Yang Mei#*, Xu Han, Yijie Liu, Jing Yang, Ronen Sumagin, and Peng Ji*. Diaphanous-related formin mDia2 regulates beta2 integrins to control hematopoietic stem and progenitor cell engraftment. Nat Commun. 2020 Jun 23;11(1):3172. (Co-corresponding author) (IF= 17.694)
7. Yang Mei, Baobing Zhao, Ashley A Basiorka, Jing Yang, Lan Cao, JingxinZhang, Alan List, and Peng Ji*. Age-related inflammatory bone marrow microenvironment induces ineffective erythropoiesis mimicking del(5q) MDS. Leukemia. 2018,32(4):1023-1033. (IF= 12.883)
8. Baobing Zhao, Yang Mei, Lan Cao, Jingxin Zhang, Ronen Sumagin, Jing Yang, Juehua Gao, Matthew J. Schipma, Yanfeng Wang, Chelsea Thorsheim, Liang Zhao, Timothy Stalker, Brady Stein, Qiang Jeremy Wen, John D. Crispino, Charles S. Abrams, and Peng Ji*. Loss of pleckstrin-2 reverts lethality and vascular occlusions in JAK2V617F-positive myeloproliferative neoplasms. J Clin Invest. 2018, 128(1):125-140. (IF= 19.456)
9. Yang Mei, Gong Feng, Nina Rahimi, Baobing Zhao, Jingxin Zhang, Lan Cao, Jing Yang, Juehua Gao, Yihua Chen, Ronen Sumagin, William A. Muller, Ling Zhang and Peng Ji*. Loss of mDia1 causes neutropenia via attenuated CD11b endocytosis and increased neutrophil adhesion to the endothelium. Blood Advances. 2017,1:1650-1656. (IF= 7.637)
10. Xuehui Li#, Yang Mei#, Bowen Yan#, Eric Vitriol, Suming Huang*, Peng Ji*, and Yi Qiu*. Histone deacetylase 6 regulates cytokinesis and erythrocyte enucleation through deacetylation of formin protein mDia2. Haematologica. 2017, 102(6): 984-994. (IF= 11.047)
11. Yang Mei, Baobing Zhao, Jing Yang, Juehua Gao, Amittha Wickrema, Dehua Wang, Yihua Chen, Peng Ji*. Ineffective Erythropoiesis Caused by Binucleated Late-Stage Erythroblasts in mDia2 Hematopoietic Specific Knockout Mice. Haematologica. 2016, 101(1): e1–e5. (IF= 11.047)
12. Baobing Zhao, Yang Mei, Matthew J. Schipma, Eric Wayne Roth, Reiner Bleher, Joshua Z. Rappoport, AmitthaWickrema, Jing Yang, Peng Ji*. Nuclear Condensation during Mouse Erythropoiesis Requires Caspase-3-Mediated Nuclear Opening, Dev Cell. 2016, 36(5):498-510. (IF= 12.270, Cover Story)
Comment in: Chromatin Condensation and Enucleation in Red Blood Cells: An Open Question. Margaret H Baron, Jeffrey Barminko. Dev Cell. 2016, 36(5):481-2.
13. Ganesan Keerthivasan#, Yang Mei#, Baobing Zhao, Ling Zhang, Chad E. Harris, Juehua Gao, Ashley A. Basiorka, Matthew J. Schipma, James McElherne, Jing Yang, Amit K. Verma, Andrea Pellagatti, Jacqueline Boultwood, Alan F. List, David A. Williams, and Peng Ji*. Aberrant overexpression of CD14 on granulocytes sensitizes the innate immune response in mDia1 heterozygous del(5q) myelodysplastic syndromes. Blood. 2014, 124(5): 780-90. (IF= 25.476)
Comment in: Errant innate immune signaling in del(5q) MDS. Starczynowski DT. Blood. 2014, 31; 124(5): 669-71.
14. Yang Mei#, Zhanxiang Wang#, Lei Zhang#, Yiru Zhang, Xiaoyu Li, Huihui Liu, Jing Ye, and Han You*. Regulation of neuroblastoma differentiation by forkhead transcription factors FOXO1/3/4 through the receptor tyrosine kinase PDGFRA. Proc Natl Acad Sci U S A. 2012, 109(13): 4898-903. (IF= 12.779)
15. Yang Mei#, Yiru Zhang#, Kazuo Yamamoto, Wei Xie, Tak W. Mak and Han You*. FOXO3a-dependent regulation of Pink1 (Park6) mediates survival signaling in response to cytokine deprivation. Proc Natl Acad Sci U S A. 2009, 106(13): 5153-8. (IF= 12.779)
Editors' Choice: Cell Survival, In the Pink1 with FOXO3a. Elizabeth MA, Sci. Signal. 2009, 2 (65), ec122.
16. Lei Zhang, Yang Mei, Nai-yang Fu, Li Guan, Wei Xie, Hui-hui Liu, Chun-dong Yu, Zhenyu Yin, Victor C. Yu, and Han You*. TRIM39 regulates cell cycle progression and DNA damage responses via stabilizing p21. Proc Natl Acad Sci U S A. 2012, 109(51):20937-42. (IF= 12.779)
奖励与荣誉
2007 国家奖学金，教育部
2012 博士研究生国家奖学金，教育部
2015 Katten Muchin Rosenman Travel Scholarship award, Northwestern University
2016 ASH Abstract Achievement Award, 美国血液学会ASH
2017 Katten Muchin Rosenman Travel Scholarship award, Northwestern University
2017 Lurie Cancer Center-NUCATS Joint Translational Bridge Program Award, Northwestern University
2017 OPA Professional Development Travel Awards, Northwestern University
2021 ASH Global Research Award, 美国血液学会ASH
课题组更多信息及更新详见：https://www.x-mol.com/groups/Meiyang
