人才队伍

黄静

时间:2021年08月11日 22:11 点击: 字体大小:

基本情况

湖南大学,生命医学交叉研究院,教授/博士生导师,入选“湖南省百人计划”,先后主持国家自然科学基金青年项目、面上项目、海外合作项目多项。E-mail: huangjing16@hnu.edu.cn


教育经历

2005-2010 武汉大学,化学生物学,博士

2001-2005 湖南农业大学,应用化学专业,本科


工作经历

2021至今 生命医学交叉研究院

2017年至今 化学生物传感与计量国家重点实验室

2016年-至今 湖南大学生物学院,化学生物学与纳米医学研究所

2010-2015 美国国立卫生研究院(NIH),博士后


研究领域

黄静教授课题组的研究领域主要是通过化学工具和手段,对生物大分子进行修饰、调控;研究DNA从识别到修饰、从损伤到修复的过程。从分子水平研究细胞衰老、死亡的机理,为相关疾病靶向治疗提供理论基础和新思路。研究方向涉及化学生物学,细胞生物学,药学、基础医学等多学科的交叉。具体研究方向包括:

1、DNA损伤修复机理与基因组的稳定性

2、生物大分子的化学调控

3、靶向药物的设计及其作用机理研究

诚挚欢迎化学、生命科学、基础医学以及相关交叉学科背景的优秀硕/博生加入,热烈欢迎博士后、助理教授、副教授等加盟合作。


科研项目

1. 国家自然科学基金青年项目,21708007,DNA转位酶FANCM抑制剂的筛选及其在DNA交联损伤修复通路中的作用研究,2018.01-2020.12,主持。

2. 国家自然科学基金面上项目,31871365,基于DNA纤维荧光原位杂交技术的DNA交联损伤修复研究,2019.01-2022.12,主持。

3. 国家自然科学基金海外合作项目,21828701,泛素化组蛋白H4探针的设计合成以及在基因损伤修复中的应用,2019.01-2020.12

4. 黄静,湖南省自然科学基金青年项目,2018JJ3030,基于活性氧激活的RNA G-四链体探针的设计、合成及其生物活性研究,2018.01-2020.12,主持。


代表论文

1. Guorui Li#, Yi Yang #, Yaya Zhang, Peiling Huang,      Jiangyu Yan, Zhibin Song, Quan YuanJing Huang*A      Reactive Oxygen Species-Tyrosinase Cascade Activated Prodrug for      Selectively Suppressing MelanomaCCS Chemistry 2021, 3,      1622–1638.

2. Song Liu, Lingli Bu, Yuming Zhang, Jiangyu Yan, Ling Li, Guorui Li *, Zhibin Song *, Jing Huang *, Subtle Structural Changes of Dyes Lead to Distinctly Different Fluorescent Behaviors in Cellular Context: The Role of G-Quadruplex DNA Interaction Using Coumarin-Quinazolinone Conjugates as a Case Study, Analytical Chemistry, 2021, 93, 12, 5267-5276.

3. Jing Huang*, Jing Zhang, Marina A. Bellani, Durga Pokharel, Julia Gichimu, Ryan C. James, Himabindu Gali, Chen Ling, Zhijiang Yan, Dongyi Xu, Junjie Chen, Amom Ruhikanta Meetei, Lei Li, Weidong Wang, Michael M. Seidman*, Remodeling of Interstrand Crosslink Proximal Replisomes Is Dependent on ATR, FANCM, and FANCD2, Cell Reports, 2019, 27(6), 1794-1808.

4. Florian Rohleder#, Jing Huang#, Yutong Xue, Jochen Kuper, Adam Round, Michael Seidman*, Weidong Wang*, and Caroline Kisker*, FANCM interacts with PCNA to promote replication traverse of DNA interstrand crosslinks, Nucleic Acids Research, 2016, 44, 3219–3232.

5. Jing Huang, Shuo Liu, Marina A. Bellani, Arun Kalliat Thazhathveetil, Chen Ling, Johan P. de Winter, Yinsheng Wang, Weidong Wang, and Michael M. Seidman*, “The DNA Translocase FANCM/MHF Promotes Replication Traverse of DNA Interstrand Crosslinks”, Molecular Cell. 2013, 52, 434–446.

6. Xiaolin Wang#, Jing Huang#, Yangyang Zhou, Shengyong Yan, Xiaocheng Weng, Xiaojun Wu, Minggang Deng, Xiang Zhou*Conformational Switching of G-Quadruplex DNA by PhotoregulationAngewandte Chemie International Edition, 2010 , 49, 5305-539.


其他论文

1. Song Liu, Han Su, Lingli Bu, Jiangyu Yan, Guorui Li , Jing Huang*, Fluorogenic Probes for Mitochondria and Lysosomes via Intramolecular Photoclick Reaction Analyst, 2021, 146, 1369-1375.

2. Tao Luo, Lingli Bu, Siyu Peng, Yaya Zhang, Zhi Zhou, Guorui Li*, Jing Huang*, One-step microwave-assisted preparation of oxygen-rich multifunctional carbon quantum dots and their application for Cu2+-curcumin detection, Talanta, 2019, 205, 120117-120125.

3. Jihuan Yang, Yaya Zhang, Xuejiao Bai, Guorui Li*, Zhiming Xing, Cheng Zhong, Jia Zhou, Song Liu, Zhibin Song*, Jing Huang*, Coumarin-Quinazolinone conjugate with large two photon action cross-section assisted by intramolecular hydrogen bond for bioimaging, Sensors & Actuators: B. Chemical, 2019, 297, 126720-126729.

4. Lingli Bu, Tao Luo, Huanjun Peng, Ling Li, Dengying Long, Jingdong Peng*, Jing Huang*, One-step synthesis of N-doped carbon dots, and their applications in curcumin sensing, fluorescent inks, and super-resolution nanoscopy, Microchimica Acta, 2019, 186, 675-686.

5. Lu Liu, Yaya Zhang, Jia Zhou, Jihuan Yang, Cheng Zhong, Yueshou Zhang, Yu Luo, Yang Fua, Jing Huang*, Zhibin Song*, Yiyuan Peng, Design of a quinazolinone-based environment-sensitive fluorescent dye: Solvatochromic fluorescence and application for one-photon and two-photon bioimaging, Dyes and Pigments, 2019, 165, 58-64.

6. Jing Huang, Himabindu Gali, Julia Gichimu, Marina A. Bellani, Durga Pokharel, Manikandan Paramasivam, Michael M. Seidman*, Single Molecule Analysis of Laser Localized Psoralen Adducts, Jounal of Visualized Experiments, 2017122, 55541-55547.

7. Jing Huang, Himabindu Gali, Manikandan Paramasivam, Parameswary Muniandy, Julia Gichimu, Marina A. Bellani and Michael M. Seidman*, Single molecule analysis of laser localized interstrand crosslinks. Frontiers in Genetics, 2016, 7, 84-93.

8. Chen Ling, Jing Huang, Zhijiang Yan, Yongjiang Li, Mioko Ohzeki, Masamichi Ishiai, Dongyi Xu, Minoru Takata, Michael Seidman*, and Weidong Wang*, Bloom syndrome complex promotes FANCM recruitment to stalled replication forks and facilitates both repair and traverse of DNA interstrand crosslinks, Cell Discovery, 2016, 2, 16047.

9. Minghui Bai, Jing Huang, Xiaolong Zheng, Zhibin Song, Miru Tang, Wuxiang Mao, Libo Yuan, Jun Wu, Xiaocheng Weng, Xiang Zhou *, Highly Selective Suppression of Melanoma Cells by Inducible DNA Cross-Linking Agents: Bis(catechol) Derivatives, Journal of the American Chemical Society, 2010, 132, 15321-15327.

10. Jing Huang, Ming Wang, Yangyang Zhou; Xiaocheng Weng, Liang Shuai, Xiang Zhou *, Deqing Zhang, Visual observation of G-quadruplex DNA with the label-free fluorescent probe silole with aggregation-induced emission, Bioorganic & Medicinal Chemistry, 2009, 17(22), 7743-7748.

11. Jing Huang#, Guorui Li#, Zhiguo Wu, Zhibin Song, Yangyang Zhou, Liang Shuai, Xiaocheng Weng, Xiang Zhou *, Guangfu Yang, Bisbenzimidazole to benzobisimidazole: from binding B-form duplex DNA to recognizing different modes of telomere G-quadruplex, Chemical Communications, 2009, 8, 902-904.

12. Guorui Li#, Jing Huang#, Ming Zhang, Yangyang Zhou, Dan Zhang, Zhiguo Wu, Shaoru Wang, Xiaocheng Weng, Xiang Zhou *, Guangfu Yang, Bis(benzimidazole)pyridine derivative as a new class of G-quadruplex inducing and stabilizing ligand, Chemical Communications, 2008, 38,4564-4566.

13. Boqiao Fu#, Jing Huang#, Lige Ren, Xiaocheng Weng, Yangyang Zhou, Yuhao Du Xiaojun Wu, Xiang Zhou *, Guangfu Yang, Cationic corrole derivatives: a new family of G-quadruplex inducing and stabilizing ligands, Chemical Communications, 2007, 31, 3264-3266.

14. An-Ming Zhang#, Jing Huang#, XiaoCheng Weng, JinXi Li, Lige Ren, ZhiBin Song, XiaoQin Xiong, Xiang Zhou *, XiaoPing Cao, Yan Zhou, A water-soluble, octacationic zinc phthalocyanine as molecular probe for nucleic acid secondary structure, Chemistry & Biodiversity, 2007, 4(2), 215-223.


奖励与荣誉

2014美国国立卫生研究院(NIH)优秀博士后研究员奖

2013美国国立卫生研究院(NIH)优秀博士后研究员奖